Plasticity of Vascular Smooth Muscle α-Actin Gene Transcription
نویسندگان
چکیده
منابع مشابه
α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse vasculopathies such as thoracic aortic aneurysms and dissections as well as occlusive vascular diseases, including premature coronary artery d...
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Abstract Introduction: Myofibroblasts are the main stromal components that constitute the desmoplastic reaction of host cells to inductive stimuli exerted by tumor cells. The purpose of this study was to evaluate the score of myofibroblasts using α -smooth muscle actin marker (α–SMA) in mucoepidermoid carcinoma (MEC) in comparison with pleomorphic adenoma (PA)and study the amount presence of t...
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The most common genetic alterations for familial thoracic aortic aneurysms and dissections (TAAD) are missense mutations in vascular smooth muscle (SM) α-actin encoded by ACTA2 We focus here on ACTA2-R258C, a recurrent mutation associated with early onset of TAAD and occlusive moyamoya-like cerebrovascular disease. Recent biochemical results with SM α-actin-R258C predicted that this variant wil...
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Mural cells of the vascular system include vascular smooth muscle cells (SMCs) and pericytes whose role is to stabilize and/or provide contractility to blood vessels. One of the earliest markers of mural cell development in vertebrates is α smooth muscle actin (acta2; αsma), which is expressed by pericytes and SMCs. In vivo models of vascular mural cell development in zebrafish are currently la...
متن کاملStructure/Function Analysis of Mouse Pur , a Single-stranded DNA-binding Repressor of Vascular Smooth Muscle -Actin Gene Transcription*
Plasticity of smooth muscle -actin gene expression in fibroblasts and vascular smooth muscle cells is mediated by opposing effects of transcriptional activators and repressors. Among these factors, three singlestranded DNA-binding proteins, Pur , Pur , and MSY1, have been implicated as coregulators of a cryptic 5 enhancer module. In this study, a molecular analysis of Pur , the least well chara...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.19.11310